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Rotman M, Welling MM, Bunschoten A, de Backer ME, Rip J, Nabuurs RJA, Gaillard PJ, van Buchem MA, van der Maarel SM, van der Weerd L (2015) Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimers disease

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We observed the same in our cohort of 70 patients: compared to patient matched healthy tissue, tumors had significantly higher levels of GSSG which they appeared to redox-balance by enhancing GSH production, reflected by a an accumulation of GSH as well as its precursors (Fig

In mouse hearts that underwent myocardial infarction, with a uniform distribution of B-017 throughout the cardiac tissue, the typical hallmarks of both apoptosis and necrosis have been markedly reduced, while the cardiac metabolism has undergone a notable alteration upon B-017 administration